Table 4.

PheWAS of GIGYF1 pLOF – quantitative traits.

Gene	Variant set	Title	p-value	Effect (SD)	95% CI−	95% CI+	n carrier measured
GIGYF1	pLOF	HbA1c	1.28 × 10–14	0.64	0.48	0.80	129
GIGYF1	pLOF	Cholesterol	2.44 × 10–12	− 0.61	− 0.78	− 0.44	128
GIGYF1	pLOF	Glucose	4.42 × 10–12	0.62	0.44	0.79	121
GIGYF1	pLOF	LDL cholesterol	2.40 × 10–10	− 0.56	− 0.73	− 0.38	128
GIGYF1	pLOF	Apolipoprotein b	2.52 × 10–10	− 0.56	− 0.73	− 0.39	127
GIGYF1	pLOF	LH grip strength	5.11 × 10–10	− 0.37	− 0.49	− 0.25	131
GIGYF1	pLOF	RH grip strength	1.01 × 10–8	− 0.34	− 0.46	− 0.23	131
GIGYF1	pLOF	Peak expiratory flow	5.73 × 10–8	− 0.41	− 0.56	− 0.26	114
GIGYF1	pLOF	Cystatin c	6.65 × 10–6	0.36	0.20	0.51	128
GIGYF1	pLOF	Mean corpuscular hemoglobin	6.80 × 10–6	− 0.38	− 0.55	− 0.22	128
GIGYF1	pLOF	HDL cholesterol	1.53 × 10–5	− 0.35	− 0.52	− 0.19	121
GIGYF1	pLOF	Time to complete round (cognitive test)	1.67 × 10–5	0.35	0.19	0.51	129
GIGYF1	pLOF	Waist circumference	3.98 × 10–5	0.32	0.16	0.47	130
GIGYF1	pLOF	Total protein	6.45 × 10–5	− 0.36	− 0.53	− 0.18	121
GIGYF1	pLOF	Apolipoprotein a	6.88 × 10–5	− 0.33	− 0.49	− 0.17	121

Significant associations with quantitative traits are shown (p ≤ 1.22 × 10^–4). Effect is shown in standard deviations (SD) of transformed values.

RH right hand, LH left hand, CI confidence interval.