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. 2021 Nov 3;11:21568. doi: 10.1038/s41598-021-00428-x

Table 2.

Crude and adjusted odds ratios of influenza and URI (previous 1–14, 1–30, and 1–90 days) for COVID-19 infection in all participants.

Characteristics COVID-19 (exposure/total, %) Control (exposure/total, %) ORs (95% confidence interval) for COVID-19 E-value (95% CI)
Crude P-value Model 1†‡ P-value Model 2§ P-value
Previous 1–14 days
Influenza 27/8,070 (0.3%) 20/32,280 (0.1%) 5.62 (3.16–9.98)  < 0.001* 5.37 (3.01–9.60)  < 0.001* 3.07 (1.61–5.85) 0.001* 5.59 (2.60–11.18)
URI 1,441/8,070 (17.9%) 1,003/32,280 (3.1%) 6.82 (6.26–7.43)  < 0.001* 7.00 (6.42–7.62)  < 0.001* 6.95 (6.38–7.58)  < 0.001* 13.38 (12.24–14.64)
Previous 1–30 days
Influenza 32/8,070 (0.4%) 48/32,280 (0.1%) 2.68 (1.71–4.19)  < 0.001* 2.46 (1.56–3.87)  < 0.001* 1.18 (0.72–1.91) 0.510 1.00 (1.00–1.67)
URI 1,741/8,070 (21.6%) 1,741/32,280 (5.4%) 4.87 (4.53–5.23)  < 0.001* 5.00 (4.65–5.38)  < 0.001* 4.99 (4.64–5.37)  < 0.001* 9.45 (8.75–10.21)
Previous 1–90 days
Influenza 146/8,070 (1.8%) 229/32,280 (0.7%) 2.60 (2.10–3.20)  < 0.001* 2.52 (2.04–3.12)  < 0.001* 1.91 (1.54–2.37)  < 0.001* 3.23 (2.45–4.17)
URI 2,694/8,070 (33.4%) 5,130/32,280 (15.9%) 2.68 (2.54–2.84)  < 0.001* 2.73 (2.58–2.89)  < 0.001* 2.70 (2.55–2.86)  < 0.001* 4.84 (4.54–5.17)

*Conditional logistic regression model, Significance at P < 0.05.

Stratified model for age, sex and income.

Model 1 was adjusted for CCI scores, asthma, COPD, and hypertension.

§Model 2 was adjusted for model 1 plus influenza and URI.