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. 2021 Nov 3;4:1260. doi: 10.1038/s42003-021-02788-6

Fig. 4. Postnatal degeneration of hair cells and neurons in Chd7 mutants.

Fig. 4

a Auditory brainstem response (ABR) tests of Atoh1Cre/+;Chd7flox mutants and controls at 4 weeks and 8 weeks reveals profound hearing loss in homozygous and mild-moderate hearing loss in heterozygous Chd7 mutants across all frequencies. b ABR tests of NeuroD1Cre/+;Chd7flox mutants and controls at 4 weeks and 8 weeks reveals mild-moderate hearing loss in homozygous mutants. Frequencies where significant threshold elevations were observed are indicated by asterisks (P-values: *< 0.05, **< 0.005, ***< 0.0005, ****< 0.000005). See Figs. S5 and S6 for ABR profiles of each mouse. Error bars represent the standard error of mean (see Figs. S5 and S6). CTRL = control; HET = heterozygote; HOM = homozygote.