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. 2021 Oct 21;8:739227. doi: 10.3389/fmolb.2021.739227

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Copyright © 2021 Wang, Zhou, Liu, Yang, Mi, Han, Han, Chen, Liu, Zheng, Zhang, Lin, Li, Hong, Li and Guo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Flow chart of the research design. 6,476 patients were screened for emergency agitation, and 24 patients developed EA. 36 non-EA patients were matched with a ratio of 1:1.5 according to gender, age, BSA, and surgery types. Finally, 16 valid preoperative blood samples in the EA group and 34 valid preoperative blood samples in the non-EA group were collected for further analyses.