TABLE 3.

Altered metabolites in the serum between the EA group and the non-EA group undergoing elective surgeries under general anesthesia.

Metabolites	ESI+/−	Super class	VIP	FC	p-value	Q-value	Trend
Allantoin	−	Organoheterocyclic compounds	2.87	4.47	0.003	0.018	Up
Theophylline	−	Organoheterocyclic compounds	2.18	4.39	0.001	0.010	Up
Cytidine	−	Nucleosides, nucleotides, and analogues	2.77	3.29	0.005	0.028	Up
Succinic acid semialdehyde	−	Lipids and lipid-like molecules	1.15	3.13	0.006	0.031	Up
D-2,3-Dihydroxypropanoic acid	−	Organic oxygen compounds	2.41	2.02	0.001	0.012	Up
Allopurinol	−	Organoheterocyclic compounds	1.97	0.41	<0.001	0.002	Down
Gamma-linolenic acid	−	Lipids and lipid-like molecules	1.93	0.20	<0.001	0.002	Down
Sedoheptulose	−	Organic oxygen compounds	2.50	0.20	<0.001	<0.001	Down
Inosine	−	Nucleosides, nucleotides, and analogs	2.69	0.13	<0.001	<0.001	Down
Tolmetin	+	Organic oxygen compounds	1.88	6.10	0.006	0.016	Up
Oleamide	+	Lipids and lipid-like molecules	2.16	5.33	0.004	0.013	Up
Glycerophosphocholine	+	Lipids and lipid-like molecules	2.62	4.12	0.002	0.009	Up
Trigonelline	+	Alkaloids and derivatives	1.44	4.05	0.024	0.038	Up
Decanoylcarnitine	+	Lipids and lipid-like molecules	1.45	2.67	0.026	0.040	Up
L-Cycl o(alanylglycyl)	+	Organoheterocyclic compounds	1.32	2.62	0.004	0.013	Up
L-alpha-Aspartyl-l-hydroxyproline	+	Organic acids and derivatives	1.35	2.58	0.021	0.036	Up
4,8 Dimethylnonanoyl carnitine	+	Lipids and lipid-like molecules	1.18	2.42	0.011	0.023	Up
Choline	+	Organic nitrogen compounds	2.68	2.31	<0.001	0.001	Up
1-Pyrrolidinecarboxaldehyde	+	Organoheterocyclic compounds	1.25	2.24	0.035	0.048	Up
2-Methylbutyroylcarnitine	+	Lipids and lipid-like molecules	2.09	2.17	<0.001	0.003	Up
PC(P-18:1 (11Z)/20:5 (5Z,8Z,11Z,14Z,17Z))	+	Lipids and lipid-like molecules	1.09	2.16	0.011	0.024	Up
Montecristin	+	Lipids and lipid-like molecules	2.45	2.07	<0.001	0.002	Up
l-Phenylalanine	+	Organic acids and derivatives	2.61	2.06	<0.001	<0.001	Up
Hypoxanthine	+	Organoheterocyclic compounds	1.76	0.47	0.002	0.008	Down
Isoleucyl-alanine	+	Organic acids and derivatives	1.35	0.37	<0.001	0.003	Down
Desglucocheirotoxin	+	Lipids and lipid-like molecules	2.29	0.23	<0.001	<0.001	Down
Isoleucyl-valine	+	Organic acids and derivatives	2.38	0.17	<0.001	<0.001	Down
Arabinosylhypoxanthine	+	Nucleosides, nucleotides, and analogs	2.17	0.13	<0.001	<0.001	Down
2-(3,4-Dihydroxybenzoyloxy)-4,6-dihydroxybenzoate	+	Phenylpropanoids and polyketides	2.34	0.11	<0.001	<0.001	Down
Sertindole	+	Organoheterocyclic compounds	1.27	0.02	<0.001	0.003	Down
8beta-Angeloyloxy-15-hydroxy-1alpha,10R-dimethoxy-3-oxo-11(13)-germacren-12,6alpha-olide	+	Lipids and lipid-like molecules	1.35	0.02	<0.001	0.002	Down

Note: ESI, electrospray ionization; VIP, variable importance in the projection; FC, fold change.