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. 2021 Nov 3;11:21619. doi: 10.1038/s41598-021-00781-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Methylation discordance and analysis regions in the targeted breast normal/cancer comparison. (a) Venn diagram showing the number of analysis regions overlapping all genomic regions examined that exhibited significant differences in mean methylation level (MML) and normalized methylation entropy (NME), as well as significant discordance in the probability distribution of methylation quantified by the coefficient of methylation divergence (CMD). (b) Venn diagram of significantly dysregulated analysis regions that overlap gene bodies. (c) Venn diagram of significantly dysregulated analysis regions that overlap promoter regions. (d) Venn diagram of significantly dysregulated analysis regions that overlap known repetitive elements.