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. 2021 Nov 3;12:6340. doi: 10.1038/s41467-021-26570-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a, b Clonogenic survival following irradiation and either A-485 (active) or A-486 (inactive) in CREBBP/EP300 mutant (a) or wild-type (b) HNSCC cells. c Surviving fraction at 4 Gy for each cell line (highest dose of A-485/A-486 shown). d, e TUNEL assay (d) and caspase 3 cleavage (e) in UM-SCC-47 (CREBBP mut), and HN5 (CREBBP/EP300 mut) and HN31 (CREBBP/EP300 wt) cells treated with radiation and either A-485 (active) or A-486 (inactive). For a–e, a minimum of three independent samples for each condition are shown and are presented as mean values +/− SEM with (*, #) -p < 0.05 vs. control (*) and A-486 (#). p-values are two-sided and derived from ANOVA with post hoc analysis adjusted for multiple comparisons.