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. 2021 Nov 3;7:333. doi: 10.1038/s41420-021-00725-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Top, flow chart demonstrates the selection criteria of potential piRNAs dysregulated in ccRCC. Bottom, heatmap showing the differential expression of piRNAs in 2 pairs of ccRCC and adjacent normal samples by piRNA sequencing. b Expression of piR-57125 in ccRCC and normal patients based on the analysis of TCGA data. c qRT-PCR analysis of piR-57125 expression in 45 paired ccRCC and adjacent normal samples from patients recruited from the SRRSH cohort. Data represent mean ± S.D. d RIP and RT-qPCR assay showed that PIWIL4 has more affinity to piR-57125 in OSRC-2 cells compared with PIWIL1 and PIWIL2. e Cytoplasm and nuclear mRNA fractionation experiment showed that piR-57125 exists in both the cytoplasm and the nucleus. U6 and GAPDH act as the positive controls of nucleus and cytoplasm, respectively. **p < 0.01; ***p < 0.001.