Fig. 1.

Summary of known approaches for reprogramming glial cells into neurons. The diagram illustrates the three approaches that have been used to induce the reprogramming of glial cells into neurons: (1) the over-expression of a single TF or TF cocktail including direct and indirect approaches (e.g., via neuroblasts or immature neurons by SOX2 or Ngn2 signaling); (2) the use of small chemical molecules; and (3) suppression of the PTB gene.