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. 2021 Oct 21;12:682082. doi: 10.3389/fgene.2021.682082

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Copyright © 2021 Wang, Ge, Zhang, Ye, Zhou, Li, Yan, Wu, Bai, Li, Zhu and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Construction and validation of the ferroptosis-related lncRNA signature. (A) Lasso coefficient profiles indicated that 11 ferroptosis-related lncRNAs should be retained in the model. (B) The K-M curve showed that the high-risk group (red curve) had a poorer OS than the low-risk group (blue curve) in TCGA cohort. (C) ROC curve of the ferroptosis-related lncRNA model. The AUCs of 1-, 3-, and 5 years OS were 0.772, 0.707, and 0.666, respectively. (D) The prognostic difference between high- and low-risk patients of GSE76427. (E) Univariate analysis and (F) Multivariate analysis of the lncRNA model and clinical features. lncRNA: long noncoding RNA; Lasso: least absolute shrinkage and selection operator; K-M curve: Kaplan–Meier curve; OS: overall survival; ROC curve: receiver‐operating characteristic curve.