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. 2021 Oct 21;12:682082. doi: 10.3389/fgene.2021.682082

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Copyright © 2021 Wang, Ge, Zhang, Ye, Zhou, Li, Yan, Wu, Bai, Li, Zhu and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Validation of the ferroptosis-related lncRNA model in TICs and immunotherapy. The scores of (A) 16 immune cell subpopulations and (B) 13 immune-related functions varied in the high- and low-risk groups. (C–I) The correlation between seven important checkpoint molecules and the risk scores of HCC patients. (J) The relationship between risk score and response to immunotherapy was determined using the TIDE algorithm. (K) The relationship between T cell dysfunction and log2 (risk score). lncRNA: long noncoding RNA; TIC: tumor-infiltrating immune cells; TIDE: tumor immune dysfunction and exclusion. Log2: data log2 transformed.