Table 1.
Consistently dysregulated miRNAs reported in at least two expression profiling studies.
| miRNA | Chromosome location | Studies/References | No. of ASD samples (male: female) | Male: female ratio of ASD samples | No. of autism risk genes targeted by the miRNAa |
|---|---|---|---|---|---|
| Upregulated | |||||
| miR-146a-5p | 5 | (11, 17, 34, 42, 54) | N/A | N/A | 24 |
| miR-155-5p | 21 | (11, 13, 18) | 63:12 | 5–6: 1 | 77 |
| miR-106a-5p | X | (10, 22) | 27:2 | 13–14: 1 | 49 |
| miR-10a-5p | 17 | (13, 36) | 58:17 | 3–4: 1 | 43 |
| miR-335-3p | 7 | (13, 38) | 64:15 | 4–5: 1 | 35 |
| miR-142-3p | 17 | (11, 28) | 34:8 | 4–5: 1 | 34 |
| miR-23b-3p | 9 | (34, 35) | 14:3 | 4–5: 1 | 28 |
| miR-107 | 10 | (13, 35) | 56:10 | 5–6: 1 | 27 |
| miR-223-3p | X | (13, 37) | 45:10 | 4–5: 1 | 11 |
| miR-146b-5p | 10 | (10, 34) | 16:3 | 5–6:1 | 13 |
| miR-483-5p | 11 | (26, 32) | 105:20 | 5–6:1 | 8 |
| miR-21-3p | 17 | (11, 13) | 55:12 | 4–5:1 | 6 |
| miR-191-5p | 3 | (35, 38) | 30:5 | 6:1 | 5 |
| miR-1277-3p | X | (13, 54) | 45:11 | 4–5:1 | 1 |
| miR-494 | 14 | (11, 26) | 27:5 | 5–6:1 | N/A |
| Downregulated | |||||
| miR-15a-5p | 13 | (10, 26, 28) | 54:9 | 6:1 | 73 |
| let-7a-5p | 9, 11, 22 | (11, 26, 39) | 188:31 | 6–7:1 | 48 |
| miR-193a-5p | 17 | (29, 32, 39) | 256:43 | 5–6:1 | 3 |
| miR-92a-3p | X, 13 | (26, 34) | 20:6 | 3–4:1 | 118 |
| miR-15b-5p | 3 | (10, 26) | 30:3 | 10:1 | 91 |
| miR-20a-5p | 13 | (26, 32) | 105:20 | 5–6:1 | 71 |
| miR-148b-3p | 12 | (10, 35) | 24:0 | 24:0 | 45 |
| miR-211-5p | 15 | (11, 35) | 21:2 | 10–11:1 | 44 |
| miR-4742-3p | 1 | (12, 15) | 10:10 | 1:1 | 11 |
| miR-148a-5p | 7 | (32, 39) | 249:43 | 5–6:1 | 10 |
| miR-151a-3p | 8 | (19, 39) | 209:33 | 6–7:1 | 6 |
| miR-3135a | 3 | (23, 28) | 48:12 | 4:1 | 5 |
| miR-574-3p | 4 | (26, 32) | 105:20 | 5–6:1 | 3 |
| miR-3687 | 21, 22 | (13, 28) | 69:16 | 4–5:1 | 3 |
a
Based on validated target genes in miRTarbase, N/A: not available.