Table 2.

Reporting odds ratios and 95% CIs related to antidepressants and the SMQ “Gastrointestinal Haemorrhage” with and without consideration of the competition bias.

Substance	ROR without consideration of the competition bias	ROR in consideration of the competition bias
Agomelatine	0.42 (0.28–0.62)	0.51 (0.31–0.84)
Amitriptyline	1.43 (1.37–1.50)	1.65 (1.55–1.75)
Bupropion	0.69 (0.65–0.73)	0.81 (0.75–0.88)
Citalopram	1.67 (1.60–1.74)	1.50 (1.41–1.60)
Clomipramine	0.48 (0.40–0.58)	0.57 (0.45–0.73)
Doxepin	1.28 (1.14–1.43)	1.43 (1.23–1.66)
Duloxetine	1.01 (0.96–1.06)	1.13 (1.05–1.20)
Escitalopram	1.37 (1.30–1.43)	1.30 (1.22–1.40)
Fluoxetine	0.96 (0.92–1.00)	1.07 (1.01–1.14)
Fluvoxamine	0.63 (0.53–0.75)	0.79 (0.64–0.97)
Hypericum perforatum	1.02 (0.77–1.36)	0.95 (0.63–1.43)
Imipramine	0.95 (0.82–1.10)	1.10 (0.91–1.33)
Maprotiline	0.45 (0.32–0.63)	0.51 (0.33–0.79)
Milnacipran	0.46 (0.34–0.62)	0.54 (0.37–0.79)
Mirtazapine	1.41 (1.33–1.49)	1.10 (1.00–1.21)
Moclobemide	0.46 (0.33–0.65)	0.55 (0.36–0.84)
Nortriptyline	1.05 (0.93–1.17)	1.18 (1.02–1.38)
Paroxetine	1.10 (1.05–1.15)	1.04 (0.98–1.11)
Reboxetine	0.37 (0.22–0.62)	0.58 (0.34–1.00)
Sertraline	1.31 (1.26–1.36)	1.27 (1.20–1.34)
Tianeptine	1.01 (0.77–1.34)	0.48 (0.26–0.86)
Tranylcypromine	0.27 (0.14–0.52)	0.43 (0.21–0.85)
Trazodone	1.56 (1.49–1.64)	1.41 (1.31–1.52)
Trimipramine	1.14 (0.91–1.43)	1.31 (0.98–1.76)
Venlafaxine	0.97 (0.93–1.02)	1.10 (1.03–1.17)

CI, Confidence interval; ROR, reporting odds ratio; SMQ, standardized MedDRA queries.