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. 2020 Nov 6;19(4):379–385. doi: 10.5217/ir.2020.00087

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© Copyright 2021. Korean Association for the Study of Intestinal Diseases. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 1. — Mechanism suggested for diarrhea induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. During coronavirus disease (COVID-19), SARS-CoV-2 uses the angiotensin-converting enzyme 2 (ACE2) receptor and cellular serine protease transmembrane protease serine 2 (TMPRSS2) for host cell entry. ACE2 is an important regulator of amino acid transport B⁰AT1. The interaction between SARS-CoV-2 and ACE2 receptor may decrease the receptor expression leading to B⁰AT1 disruption, influencing the diarrhea observed in COVID-19 patients.