Table 2.
Clinical and Laboratory Parameters in Patients of Acute Severe Ulcerative Colitis and Comparison of Steroid Responders with Steroid Failures
| Variable | Total patients (n=76) | Steroid responder (n=46) | Steroid failure (n=30) | P-value |
|---|---|---|---|---|
| Pulse rate at admission (/min) | 100 (69–128) | 100 (80–120) | 101 (69–128) | 0.62 |
|
| ||||
| Stool frequency on admission (/day) | 10 (6–20) | 9 (6–20) | 11 (9–18) | 0.11 |
|
| ||||
| No. of Truelove criteria on admission inaddition to bloody stool frequency >6 | 0.16 | |||
| 1 | 18 (24) | 12 (26) | 6 (20) | |
| 2 | 35 (46) | 26 (56) | 9 (30) | |
| >3 | 23 (30) | 8 (17) | 15 (50) | |
|
| ||||
| Day 3 stool frequency (/day) | 7 (2–12) | 5 (2–15) | 7 (4–14) | 0.06 |
|
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| Hemoglobin on admission (g/dL) | 9.3±2.3 | 9.4±2.2 | 9.2±2.2 | 0.81 |
|
| ||||
| ESR on admission (mm/hr) | 46 (20–82) | 41 (22–78) | 47 (20–82) | 0.45 |
|
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| Albumin on admission (g/L) | 2.9±0.7 | 3.0±0.7 | 2.8±0.7 | 0.16 |
|
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| Day 3 CRP (mg/L) | 25 (3–178) | 19 (3–178) | 40 (3–137) | 0.42 |
|
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| CMV IHC positive | 12 (16) | 6 (13) | 6 (20) | 0.41 |
|
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| Positive tissue CMV PCR | 45 (59) | 24 (52) | 21 (70) | 0.15 |
|
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| Mucosal CMV DNA load (copies/mg) | 260 (0–2,700,000) | 116 (0–27,220) | 3,454 (0–2,700,000) | <0.01 |
|
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| UCEIS on admission | 5 (3–8) | 5 (3–7) | 6 (4–8) | 0.04 |
|
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| UCEIS >6 | 21 (28) | 6 (13) | 15 (50) | <0.01 |
|
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| Day 3 FCP (μg/g) | 1,115.8 (44.2–7,427.0) | 747.0 (44.2–4,062.0) | 1,383.8 (330.0–7,427.0) | <0.01 |
|
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| Day 3 FCP >1,000 μg/g | 40 (53) | 16 (35) | 24 (80) | <0.01 |
|
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| AIIMS’ index (score=2) | 15 (20) | 1 (2) | 14 (47) | <0.01 |
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| Median duration of hospitalization (day) | 11 (5–36) | 8 (5–30) | 22 (10–36) | <0.01 |
|
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| Mortality | 1 (1.3) | 0 | 1 (3.3) | |
Values are presented as median (range), number (%), or mean±standard deviation.
ESR, erythrocyte sedimentation rate; CRP, C-reactive protein; CMV, cytomegalovirus; IHC, immunohistochemistry; PCR, polymerase chain reaction; UCEIS, ulcerative colitis endoscopic severity index; FCP, fecal calprotectin; AIIMS, All India Institute of Medical Sciences.