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. 2021 Oct 21;12:726448. doi: 10.3389/fendo.2021.726448

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Copyright © 2021 Xi, Jones, Mikamoto, Jiang, Faje, Nie, Labelle, Zhou, Miller, Soberman and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immune checkpoint molecule mRNA expression in pituitary adenomas (PAs) compared to normal human pituitary tissue. (A) Comparison of relative mRNA levels of immune checkpoint molecules between aggressive PAs (gray bar, black dots) and normal human pituitary tissue (blue dots). (B) Comparison of relative mRNA levels of immune checkpoint molecules in non-aggressive PAs (gray bar, black dots) and normal human pituitary tissue samples (blue dots). *p < 0.05; **p < 0.01; ****p < 0.0001.