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. 2021 Oct 21;11:753102. doi: 10.3389/fonc.2021.753102

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Copyright © 2021 Zhou, Chen, Xiao, Wang and Rong

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HPV-related methylation-based gene signature is associated with the clinical prognosis of patients with cervical cancer. (A) Heatmap represented HPV-related gene signature expression values (rows) and tumor samples (columns) in low and high-risk groups by supervised clustering. (B) Box and whisker plots of HPV-related gene signature expression values were compared between two risk groups by t-test. The average ages (C) and the distribution of death events (D) between two risk groups were compared. (E) Overall survival of two risk groups was evaluated by Kaplan–Meier survival plot and Log-Rank test. **P < 0.01, ***P < 0.001.