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. 2021 Oct 21;9:761518. doi: 10.3389/fbioe.2021.761518

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Copyright © 2021 Yan, Li, Li and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The mice skin lesion area comparison after different treatments. (A) HC group. (B) Laser treatment. (C) Laser + ToAP2D treatment. (D) Compared with the HC group, the footpads’ size after different treatments from Day14 to 26. (E) Compared with the infection group, the footpads’ size in the laser, laser + ToAP2D, and itraconazole group from Day14 to 26. (F) Compared with the laser group, the footpads’ size in laser + ToAP2D group from Day14 to 26 (G) Analysis on the trend of the skin lesion area of all groups mice followed up time from Day14 to 26. *p < 0.05, **p < 0.01, and ***p < 0.001 indicate statistical significance.