FIGURE 5.

TTN mutation is associated with immune-related pathways. Gene set enrichment analysis was performed with the TCGA. (A) Multiple gene enrichment plot shows that a series of gene sets are enriched in the TTN-mutant group. Gene enrichment plots display that a series of immune-related gene sets, including (B) autoimmune thyroid disease, (C) B-cell receptor signaling pathway, (D) non-small-cell lung cancer, (E) primary immunodeficiency, (F) T-cell preceptor signaling pathway, (G) Toll-like receptor singling pathway, are enriched in the TTN-mutant group. NES, normalized enrichment score. The p-value is shown in each plot.