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Sensitivity of MEFs to UV irradiation or cisplatina
| MEF line | IC50
|
|
|---|---|---|
| UV radiation (J m−2) | Cisplatin (μM) | |
| +/+ | 12.0 ± 2.0 | 9.0 ± 0.5 |
| gadd45−/− | 7.0 ± 2.0 | 4.0 ± 1.0 |
| p21−/− | 8.0 ± 2.5 | 4.0 ± 1.0 |
| gadd45/p21-null | 2.0 ± 1.0 | 1.5 ± 0.5 |
| p53−/− | 1.0 ± 0.5 | 1.0 ± 0.5 |
Shown are IC50s of the indicated agents (mean of five or more independent experiments ± standard deviations). Determinations were by 7-day MTT assays.
