Table 5.
Manifestations of OXA-induced hypersensitivity reactions.
| Subjects (total=118) | N (%) | ||
|---|---|---|---|
| Symptom | Cutaneous | ||
| Flushing | 57 (48.3) | ||
| Itching | 57 (48.3) | ||
| Rash/Urticaria | 27 (22.9) | ||
| Digestive | |||
| Nausea | 35 (29.7) | ||
| Vomiting | 21 (17.8) | ||
| Others | 15 (12.7) | ||
| Neurologic | |||
| Dizziness | 7 (5.9) | ||
| Numb | 24 (20.3) | ||
| Laryngeal abnormal | 8 (6.8) | ||
| Loss of consciousness | 4 (3.4) | ||
| Respiratory | |||
| Dyspnea | 5 (4.2) | ||
| Chest discomfort | 45 (38.1) | ||
| Wheezing | 15 (12.7) | ||
| Cough | 2 (1.7) | ||
| Generalized | |||
| Sweating | 27 (22.9) | ||
| Chills | 3 (2.5) | ||
| Fever | 3 (2.5) | ||
| Cardiovascular | |||
| Hypotension | 13 (11.0) | ||
| Tachycardia | 21 (17.8) | ||
| Vision | |||
| Blurred vision | 2 (1.7) | ||
| Conjunctival congestion | 3 (2.5) | ||
| Anaphylaxis | 6 (5.1) | ||
| Others | 7 (5.9) | ||
| Grade of severity | |||
| 1 | 24 (20.3) | ||
| 2 | 76 (64.4) | ||
| 3 | 12 (10.2 | ||
| 4 | 6 (5.1) | ||
| The median time of hypersensitivity Reactions in different grades (min) | |||
| 1 | 60 (10–1440) | ||
| 2 | 19 (2–180) | ||
| 3 | 10 (5–120) | ||
| 4 | 22 (2–60) | ||
| Management | |||
| Discontinuation of oxaliplatin administration | 100 (84.7) | ||
| Histamine-receptor 1 antagonist | 61 (51.7) | ||
| Dexamethasone | 72 (61.0) | ||
| Oxygen | 34 (28.8) | ||
| Subcutaneous adrenaline | 10 (8.5) | ||