FIGURE 1.

SMYD2 expression is increased in synovial tissue and fibroblast‐like synoviocytes (FLS) from RA patients. Representative images of immunohistochemistry microscopy of SMYD2 in knee joints sections (A) and mRNA expression of SMYD2 in healthy, RA or OA patients’ synovium, data are presented as mean ± S.D; *p < 0.05, n = 3‐7/group (B). (C) SMYD2 expression is increased in TNF‐α‐induced FLS from RA patients. FLS cells were treated with TNF‐α (20 ng/ml) for the indicated times, immunoblot analyzed for SMYD2, COX2, and H3K4me. Data are presented as mean ± S.D, n = 3, ***p < 0.001 vs 0 h, Control = normal human; RA = rheumatoid arthritis; OA = osteoarthritis