FIGURE 7.

SMYD2 knockdown mice and SMYD2 inhibitor hinder the inflammation process. (A) Smyd2 ^+/‐ mice showed robust tolerance on the DSS model. (B) Smyd2 ^+/‐ mice were much more retarded to Body weights in collagen‐induced arthritis (CIA). (C) Smyd2 ^+/‐ mice showed powerful resistance to psoriasis. (D) SMYD2 selective inhibitor Bay‐598 reduced the inflammation process in DSS‐induced colitis mice model. (E) H&E staining of back skin showed Bay‐598 reduced the inflammation process in psoriasis mice model. All data are presented as mean ± S.D, n = 5, *p < 0.05, ***p < 0.001