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. 2021 Oct 21;12:737637. doi: 10.3389/fphar.2021.737637

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Copyright © 2021 Fuchs, Messerer, Karpel-Massler, Fauler, Zimmer, Jungwirth and Föhr.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Interaction of TIC 10 with the open state. The possible interaction with the open state was analyzed by means of the WCW mutant. (A) Original current traces obtained in the absence and presence of different concentrations of TIC10. Insert: experimental scheme. Cells were held at a holding potential of −140 mV. Individual activations were carried out by test-pulses to −20 mV for 500 ms after a preincubation of TIC10 for 20 s. The transient current was hardly affected while the persistent current, measured at the end of the test-pulse, was reduced in a concentration dependent manner. (B) Relative transient and persistent current amplitudes in relation to the concentration of TIC10.