Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Oct 21;12:737637. doi: 10.3389/fphar.2021.737637

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Fuchs, Messerer, Karpel-Massler, Fauler, Zimmer, Jungwirth and Föhr.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Impact of imipridones derivatives on fast inactivation. Data of normalized transient currents in the absence (open symbols) and presence of drug (filled circles) are plotted against the pre-pulse potential. Experimental scheme as in Figure 5B. (A) ONC212 shifted inactivation midpoints by −4.7 ± 0.42 mV. (B) TIC10_linear shifted inactivation midpoints by −3.0 ± 0.37 mV. Data are corrected for the endogenous shift, estimated from three preceding controls.