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. 2021 Oct 21;12:737637. doi: 10.3389/fphar.2021.737637

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Copyright © 2021 Fuchs, Messerer, Karpel-Massler, Fauler, Zimmer, Jungwirth and Föhr.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Voltage-dependence of fast inactivation. (A) Data of normalized transient currents in the absence (open symbols) and presence of TIC10 (filled circles) are plotted against the pre-pulse potential. Solid lines represent fits according to Eq. 4. Respecting the drug independent shift, inactivation midpoints shifted in the presence of 10 µM TIC10 by 1.2 ± 1.4 mV to more negative potentials. (B) Experimental scheme. Voltage-dependence of fast inactivation was determined by measuring sodium currents elicited by 5 ms depolarizations to −20 mV after conditioning pre-pulses for 500 ms to different potentials (range −140 to −45 mV).