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. 2021 Oct 21;12:737637. doi: 10.3389/fphar.2021.737637

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Copyright © 2021 Fuchs, Messerer, Karpel-Massler, Fauler, Zimmer, Jungwirth and Föhr.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Voltage-dependence of slow inactivation. (A) Relative current amplitudes in dependence of the pre-pulse potential. Solid lines are fits according to Eq. 5 for control (open circles) and TIC10 (10 μM, filled circles). (B) Normalized data with resepct to control. (C) Experimental scheme. Activations to −20 mV were elicited after long-lasting (10 s) conditioning pre-pulses to different potentials (range: −160 to 0 mV; increment 10 mV) and a short (20 ms) recovery period at −140 mV immediately before the test-pulse.