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Time-dependent interaction of imipridone derivatives with the inactivated state of the hNav1.5
| ONC212 | Amount | TIC10 linear | Amount | |
|---|---|---|---|---|
| 2.5 µM | ||||
| τ1 (s) | 0.2 ± 0.06 | 8.8 ± 4.5% | 0.2 ± 0.02 | 10.6 ± 3.1% |
| τ2 (s) | 4.6 ± 0.95 | 57.4± 6.6% | 6.7 ± 1.24 | 21.6 ± 4.5% |
| 10 µM | ||||
| τ1 (s) | 0.1 ± 0.03 | 45.2 ± 6.5% | 0.1 ± 0.02 | 29.7 ± 9.7% |
| τ2 (s) | 2.2 ± 0.27 | 46.9 ± 7.2% | 5.0 ± 1.14 | 37.4 ± 4.9% |
