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. 2021 Nov 4;19:79. doi: 10.1186/s12959-021-00333-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Dynamics of FXIII activity levels in severe COVID-19 patients. A FXIII activity levels as a function of time of hospitalization (in days). Dashed line, the lower threshold of normal FXIII activity range. B Duration of hospitalization In relation to FXIII measurement in severe COVID-19 patients with normal or with low FXIII levels (p<0.02). Normal FXIII activity was defined as activity level >79 %. Low FXIII levels were levels were defined as activity level <79 %. C Consecutive measurements of FXIII activity in 14 severe COVID-19 patients. Individual patients dynamics are shown (left), average FXIII and FVIII levels and significance are presented (right). The average interval between the two measurements is 6.1±3.4 days