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. 2021 Nov 4;19:79. doi: 10.1186/s12959-021-00333-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — A Mixing FXIII activity assay performed on plasma of four severe COVID-19 patients with low FXIII activity levels show significant increase to normal range values. Baseline and mix (1:1 with normal plasma) results are shown (p<0.0001). Dashed line, the lower threshold of normal FXIII activity range. B FXIII-A antigen levels in COVID-19 patients. FXIII-A antigen levels were determined, and correlated with FXIII activity in the same samples. R² value of the regression comparison between the antigen and activity levels are indicated. Empty circles, non-severe COVID-19 patients; Full circles, severe ICU-hospitalized COVIED-19 patients