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. 2021 Nov 4;12:565. doi: 10.1186/s13287-021-02627-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Clusters of BM-MSC transcriptome profiles. A The first two Principal Components of gene expression identify two broad clusters of cells, which are colored by sample: Cluster BM-Low, which corresponds to low UMI count cells and cluster BM-High, with high UMI count cells. B Violin plots show the density of the number of Genes, UMI, and Ribosomal Protein transcripts (RP) per cell. C Association of cells with clusters. The width of each column is proportional to the number of cells in the indicated [47] sample, and the color of each box corresponds to cells in cluster BM-Low (blue), BM-High_a (red) or BM-High_b (green). D Within cluster High, SC3 identifies two clusters of cells, which separate along PC3 as indicated by the red and blue points. E Shading of cells by sample confirms that cells from each donor belong to one of the two sub-clusters, although with subtle separation associated with PC3