Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Oct 6;297(5):101282. doi: 10.1016/j.jbc.2021.101282

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Stepwise protein–protein interactions enable Fe-S cluster biogenesis and installation to promote client release.A, the cycle of Fe-S biogenesis and transfer is depicted. 1, IscU exists in equilibrium between a structured state (S-state) and a disordered state (D-state). 2, the cysteine desulfurase IscS interacts with the D state of IscU. 3, assembly of the Fe-S cluster stabilizes the S state of IscU. 4, holo-IscU is transferred from IscS to HscB. 5, holo-IscU forms a ternary complex with HscB and HscA. 6, Fe-S cluster is transferred to the client protein, HscB is released, and HscA binds to the D state of IscU. 7, nucleotide exchange of HscA causes release of IscU. B, loading of the apo-client with the Fe-S cluster drives client release and folding.