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. 2021 Sep 13;22(11):e52864. doi: 10.15252/embr.202152864

Figure 2. The RING‐type E3 ligase LRSAM1 in Ub coat formation of cytosolic Salmonella .

Figure 2

The domain architecture of LRSAM1 showing the leucine‐rich repeats (LRR) domains (red dotted box) that detects PAMPs of Salmonella and mediates bacterial binding, coiled‐coil (CC) domains, a sterile alpha motif (SAM) containing domain, and the C terminus RING domain with E3 ligase activity. LRSAM1‐mediated ubiquitylation of cytosolic Salmonella, preferentially K6‐ and K27‐linked chains, leads to the accumulation of autophagy cargo receptor NDP52 mediating the recruitment of the autophagy machinery.