Skip to main content
. 2021 Sep 28;22(11):e52675. doi: 10.15252/embr.202152675

Figure EV3. Design of PPM1H/J chimaeras to probe substrate specificity.

Figure EV3

  1. Domain organization of PPM1H and PPM1J with locations of predicted flexible loops. Sequence identities within domains are indicated below the alignment.
  2. Heat map of PPM1H and PPM1J sequence diversity superimposed onto the ribbon model of PPM1H. The rectangular bar displays the variation from low (blue) to high (red) sequence identities.
  3. Sequence alignment of the flap domains of PPM1H and PPM1J. Secondary structure annotations of PPM1H are above the alignment. Blue and red circles below the alignment indicate conserved and non‐conserved residues subjected to site‐directed mutagenesis.