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. 2021 Oct 21;6(43):28598–28610. doi: 10.1021/acsomega.1c03009

Table 2. Radius Parameters, Mean Incidence, and Parametric Index of SeDeM Characterization of HPMC Powdersa.

  parameter (radius value)
factor
index
samples Da Dc Ie IC Icd IH α t % HR % H % Pf dimension compressibility power flow stability lubricity IP IPP IGC
K4MS 4.11 5.89 6.14 6.05 6.02 7.83 2.30 4.93 7.22 3.80 7.07 3.10 5.00 6.07 5.02 5.09 5.51 0.58 5.37 5.11
K4MT 2.93 4.79 10.00 7.76 10.00 6.83 0.67 0.00 5.91 4.73 4.87 2.04 3.86 9.25 2.50 5.32 3.46 0.42 5.04 4.80
K4M-CRT 3.06 4.87 10.00 7.45 10.00 7.03 1.27 2.47 6.24 4.94 4.57 2.14 3.97 9.15 3.59 5.59 3.36 0.42 5.34 5.08
K15MS 4.21 5.97 5.83 5.89 5.07 7.91 2.00 6.03 6.80 4.64 6.22 3.20 5.09 5.60 5.31 5.72 4.71 0.67 5.31 5.05
K15MT 3.01 5.00 10.00 7.96 10.00 6.70 0.80 0.00 6.70 5.12 5.71 2.22 4.01 9.31 2.50 5.91 3.97 0.67 5.27 5.02
K15M-CRT 3.01 4.72 10.00 7.24 10.00 7.16 0.67 0.00 5.51 5.46 4.76 1.83 3.87 9.08 2.61 5.49 3.29 0.50 5.10 4.86
K100MS 4.25 6.17 6.10 6.22 4.81 7.74 2.07 6.46 7.01 4.83 6.97 3.45 5.21 5.71 5.42 5.92 5.21 0.58 5.51 5.24
K100M-CRT 2.79 4.59 10.00 7.82 10.00 6.78 0.63 0.00 5.94 5.74 4.01 1.64 3.69 9.27 2.47 5.87 2.83 0.50 5.00 4.76
a

The results are an average of at least three measurements. K4MS, K15MS, and K100MS represent three batches of HPMC with different viscosity grades from Anhui Shanhe Pharmaceutical Excipient Co., Ltd. (China). K4MT, K4M-CRT, K15MT, K15M-CRT, and K100M-CRT represent five batches of HPMC with different viscosity grades from Dow Chemical (USA). The viscosity of K4M, K15M, and K100M is 4000, 15,000, and 100,000 mPa·s, respectively.