Table 3.

Odds of OAC treatment and receiving DOAC in relation to frailty and cognitive impairment among older patients with atrial fibrillation, SAGE-AF 2016-2018

		Odds ratio (95% confidence interval)
		Unadjusted	Model 1	Model 2
	On OAC n (%)	Odds of not receiving OAC treatment (N=1244)
No impairment	561 (85.9)	referent	referent	referent
Frailty	54 (84.4)	1.14 (0.56, 2.32)	1.55 (0.75, 3.22)	1.51 (0.70, 3.27)
CI	354 (84.5)	1.15 (0.82, 1.62)	1.34 (0.94, 1.91)	1.39 (0.94, 2.05)
Both frailty and CI	95 (88.-)	0.84 (0.45, 1.56)	1.23 (0.64, 2.35)	1.35 (0.66, 2.77)
	On DOAC n (%)	Odds of receiving a DOAC among those on OAC (n=1064)
No impairment	256 (45.6)	referent	referent	referent
Frailty	21 (38.9)	0.76 (0.43, 1.34)	0.92 (0.51, 1.64)	0.89 (0.49, 1.67)
CI	138 (39.-)	0.76 (0.58, 0.99)	0.84 (0.63, 1.10)	0.91 (0.67, 1.23)
Both frailty and CI	51 (53.7)	1.38 (0.89, 2.14)	1.73 (1.10, 2.73)	1.71 (1.02, 2.88)

Note. OAC: Oral anticoagulation; DOAC: Direct-Acting Oral Anticoagulants

Model 1 is adjusted for CHA₂DS₂VASC score, Model 2 is adjusted for Model 1 + age, education, race, marital status, has-bled score, AMI, asthma/COPD, vision impairment, hearing impairment, social support, depression, anxiety, fall in the past 6 months.