Table 4.

Odds of high treatment burden and low treatment benefit in relation to frailty and cognitive impairment among older patients with atrial fibrillation, SAGE-AF 2016-2018

	Burden and Benefit results		Odds ratio (95% confidence interval)
			Unadjusted	Model 1	Model 2
	Burden mean score (SD)	High burden n (%)	Odds of reporting high burden
No impairment	16.6 (5.2)	132 (23.5)	referent	referent	referent
Frailty	18.1 (5.6)	19 (35.2)	1.77 (0.98, 3.19)	1.74 (0.95, 3.18)	1.05 (0.54, 2.08)
CI	16.5 (6.4)	80 (22.6)	0.95 (0.69, 1.30)	0.94 (0.68, 1.30)	0.87 (0.60, 1.26)
Both frailty and CI	17.9 (6.5)	31 (32.6)	1.50 (0.93, 2.41)	1.47 (0.90, 2.42)	0.76 (0.42, 1.37)
	Benefit mean score (SD)	Low benefit n (%)	Odds of reporting low benefit
No impairment	11.3 (3.5)	98 (17.5)	referent	referent	referent
Frailty	10.2 (3.4)	15 (27.8)	1.67 (0.89, 3.20)	1.63 (0.85, 3.16)	1.22 (0.59, 2.50)
CI	10.4 (4.3)	100 (28.3)	1.88 (1.37, 2.59)	1.86 (1.35, 2.57)	1.57 (1.10, 2.24)
Both frailty and CI	9.6 (3.6)	34 (35.8)	2.67 (1.66, 4.28)	2.59 (1.58, 4.25)	1.97 (1.12, 3.47)

Note. SD: Standard Deviation,

High burden was defined as being the bottom quartile of the Anti-clot Treatment Burden Scale while low benefit was defined as being the Top quartile of the Anti-clot Treatment Benefit Scale.

Model 1 is adjusted for CHA₂DS₂VASC score, Model 2 is adjusted for Model 1 + age, education, race, marital status, has-bled score, AMI, asthma/COPD, vision impairment, hearing impairment, social support, depression, anxiety, fall in the past 6 months