REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Anti-citrullinated histone H3	Abcam	Cat# ab5103 RRID:AB_304752
Anti-rabbit Alexa 568	Invitrogen	Cat# A11011 RRID:AB_143157
Anti-Ly6G APC	BioLegend	Cat# 127613 RRID:AB_1877163
Anti-CD11b FITC	BioLegend	Cat# 101206 RRID:AB_312789
Anti-CD45 Brilliant Violet 510	BioLegend	Cat# 103138 RRID:AB_2563061
Anti-acetyl-histone H3	Sigma/Millipore	Cat# 06-599 RRID:AB_2115283
Anti-histone H3	Cell Signaling Technology	Cat# 4499 RRID:AB_10544537
Anti-caspase 8	Cell Signaling Technology	Cat# 4790 RRID:AB_10545768
Anti-cleaved caspase 8	Cell Signaling Technology	Cat# 9496 RRID:AB_561381
Anti-caspase 3	Cell Signaling Technology	Cat# 9662 RRID:AB_331439
Anti-phospho-MLKL	Cell Signaling Technology	Cat# 91689 RRID:AB_2732034
Anti-MLKL	Cell Signaling Technology	Cat# 14993 RRID:AB_2721822
Anti-GSDM-D	Cell Signaling Technology	Cat# 93709 RRID:AB_2800210
Anti-β-actin	Sigma	Cat# A2228 RRID:AB_476697
Anti-Myeloperoxidase	Sigma/Millipore	Cat# 07-496-I RRID:AB_11212795
Anti-neutrophil	Abcam	Cat# ab2557 RRID:AB_303154
Bacterial and virus strains
Staphylococcus aureus subsp. aureus Rosenbach	ATCC	Cat# 25904
Escherichia coli (O111)	ATCC	Cat# BAA-2440
Chemicals, peptides, and recombinant proteins
Ricolinostat (ACY-1215)	Cayman Chemical	Cat# 21531
Citarinostat	Cayman Chemical	Cat# 26173
GSK848 (PAD4 inhibitor)	Cayman Chemical	Cat# 17488
Entinostat	Sellckchem	Cat# S1053
Givinostat	Sellckchem	Cat# S2170
TMP195	Sellckchem	Cat# S8502
Belinostat	Sellckchem	Cat# S1085
Panobinostat	Sellckchem	Cat# S1030
FK866	Cayman Chemical	Cat# 13287
Apabetalone	Sellckchem	Cat# S7295
Deferoxamine	Cayman Chemical	Cat# 14595
Batimastat	Cayman Chemical	Cat# 14742
Tubastatin A	Cayman Chemical	Cat# 10559
Nexturastat A	Cayman Chemical	Cat# 16874
Tubacin	Cayman Chemical	Cat# 13691
Phorbol 12-myristate 13-acetate	Cayman Chemical	Cat# 10008014
Poly(I:C) HMW	Invivogen	Cat# tlrl-pic
LPS from E. coli, Serotype O55:B5 (TLRGRADE™)	Enzo Lifesciences	Cat# ALX-581-013-L002
Nigericin	Invivogen	Cat# tlrl-nig
Peroxidase from horseradish (HRP)	Sigma	Cat# P8375-1KU
Luminol	Sigma	Cat# A8511
DAPI	Invitrogen	Cat# D1306
Cell Proliferation Dye eFluor™ 670	Invitrogen	Cat# 65-0840-85
FACS Lysing Solution	BD Biosciences	Cat# 349202
Intracellular Staining Permeabilization Wash buffer	BioLegend	Cat# 421002
Diisopropylfluorophosphate	Sigma	Cat# D0879
CountBright™ Absolute Counting Beads	Invitrogen	Cat# C36950
Phosphatase inhibitors	A. G. Scientific	Cat# T-2494
Critical commercial assays
Quant-iT PicoGreen	Invitrogen	Cat# P11495
Citrullinated histone H3 ELISA kit	Cayman Chemical	Cat# 501620
Cell Death Detection ELISA	Sigma	Cat# 11544675001
TNF ELISA kit	BioLegend	Cat# 430901
IL-6 ELISA kit	BioLegend	Cat# 431301
IL-1β ELISA kit	BioLegend	Cat# 432601
Albumin Assay Kit	Abcam	Cat# ab235628
Experimental models: organisms/strains
Mouse C57BL/6J	Jackson Laboratory	Cat# 000664
Mouse C57BL/6J-Hdac6em2Lutzy/J	Jackson Laboratory	Cat# 029318
Software and algorithms
GraphPad Prism 8.0.2	GraphPad	Prism - GraphPad RRID:SCR_002798
FlowJo software	Tree star	FlowJo v10.8 RRID:SCR_008520
ImageJ	NIH	ImageJ (nih.gov) RRID:SCR_003070