Figure 7.

PFDNs are upregulated in cancer at mRNA level

Heatmap showing the log 2 of the fold change in mRNA levels of PFDNs in cancer tissues compared to adjacent normal tissue, as computed using moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 across different cancer types of TCGA. Stars represent the adjusted p value associated to the change assessed by the Wald test after normalization of RNA-seq counts (∗∗∗ = p < 0.005; ∗∗ = p < 0.01; ∗ = p < 0.05). PFDN rows are displayed according to clustering analysis of the log2FC. TCGA, The Cancer Genome Atlas; UPC, Unconventional PFDN-like Complex; FC, Fold Change