Table 2.
SOX gene activity in glioblastoma and correlation with the clinical outcome of glioblastoma patients
|
Ref.
|
Gene
|
Activity
|
Clinical outcome
|
| [94] | SOX1 | Oncogenic | Poor |
| [98-101] | SOX2 | Oncogenic | Poor |
| [104,105] | SOX3 | Possible oncogenic | No correlation /poor |
| [129-131] | SOX4 | Oncogenic in glioma-initiating cells; tumor suppressor in GBM | Poor/good |
| [115,125] | SOX5 | Tumor suppressor | Poor |
| [116,125] | SOX6 | Tumor suppressor | Poor |
| [117,127] | SOX7 | Tumor suppressor; glioma angiogenesis | Poor |
| [106-108] | SOX9 | Oncogenic | Poor |
| [110,111] | SOX10 | Possible oncogenic | Poor |
| [119] | SOX11 | Tumor suppressor | Good |
Glioblastoma: GBM.