Table 2.
Biological pathways identified in the enrichment analysis
| Category | Pathway | Overlap | P-value | FDR-corrected P-value | Odds ratio | Gene |
|---|---|---|---|---|---|---|
| Biological process | Protein oligomerization | 2/217 | 2.37 × 10−3 | 7.81 × 10− 3 | 26.33 | FCER1G, TRIM4 |
| Positive regulation of programmed cell death | 2/257 | 3.31 × 10−3 | 7.81 × 10− 3 | 22.23 | APH1B, BIN1 | |
| Positive regulation of the apoptotic process | 2/307 | 4.69 × 10−3 | 7.81 × 10− 3 | 18.61 | APH1B, BIN1 | |
| Vesicle-mediated transport | 2/410 | 8.22 × 10−3 | 1.03 × 10−2 | 13.94 | BIN1, RABEP | |
| Regulation of the apoptotic process | 2/815 | 3.04 × 10−2 | 3.04 × 10− 2 | 7.01 | APH1B, BIN1 | |
| Molecular function | Protein homodimerization activity | 2/664 | 2.07 × 10−2 | 2.07 × 10− 2 | 8.61 | FCER1G, RABEP1 |
Overlap means a ratio of the number of input genes to the number of genes associated with each biological pathway. P-values and odds ratios were obtained from Fisher’s exact test
Abbreviation: FDR false discovery rate