Table 4.
ISWI subunits with abnormal gene fusions in malignancies
| Tumors | Gene | Fusion number | Case number with fusion | Percentage (total number) |
|---|---|---|---|---|
| Adrenocortical Carcinoma | BAZ1A | 1 | 1 | 1.1%(90) |
| Bladder Urothelial Carcinoma | SMARCA5 | 1 | 1 | 0.2%(408) |
| Brain Lower Grade Glioma | RSF1 | 1 | 1 | 0.2%(511) |
| Breast Invasive Carcinoma | RSF1 | 8 | 8 | 0.8%(1070) |
| RBBP7 | 2 | 2 | 0.2%(1070) | |
| BAZ2B | 1 | 1 | < 0.1%(1070) | |
| RBBP4 | 1 | 1 | < 0.1%(1070) | |
| CHRAC1 | 1 | 1 | < 0.1%(1070) | |
| Prostate | SMARCA1 | 2 | 2 | 0.2%(494) |
| Lung Adenocarcinoma | BPTF | 1 | 1 | 0.2%(511) |
| Metastatic Solid Cancers | SMARCA1 | 2 | 2 | 0.4%(500) |
| Ovarian Serous Cystadenocarcinoma | RBBP4 | 2 | 2 | 0.4%(523) |
| RSF1 | 1 | 1 | 0.2%(523) | |
| Pancreatic Adenocarcinoma | BPTF | 1 | 1 | 0.6%(183) |
| CHRAC1 | 1 | 1 | 0.6%(179) | |
| Prostate | SMARCA1 | 2 | 2 | 0.2%(494) |
| Sarcoma | RSF1 | 2 | 2 | 0.8%(253) |
| RBBP7 | 2 | 2 | 0.8%(253) | |
| Skin Cutaneous Melanoma | RSF1 | 4 | 4 | 0.9%(440) |
| RBBP7 | 1 | 1 | 0.2%(500) | |
| Small-Cell Lung Cancer | RSF1 | 1 | 1 | 0.8%(125) |
| Uterine Corpus Endometrial Carcinoma | BAZ1B | 2 | 2 | 0.4%(500) |
All data come from the TCGA database