Table 2.
Longitudinal study of utero-placental (vascular) development trajectories and placental weight stratified by corpus luteum number
| 7 weeks | 9 weeks | 11 weeks | 13 weeks | 22 weeks | 32 weeks | At birth | ||
|---|---|---|---|---|---|---|---|---|
| GA (days) | 0 CL | 52 [51;54] | 67 [65;67] | 81 [79;81] | 96 [94;97] | 160 [157;161] | 227 [226;230] | 273 [271;280] |
| 1 CL | 51 [50;54] | 66 [65;67] | 79 [78;82] | 93 [92;94] | 157 [155;159] | 226 [224;228] | 273 [265;279] | |
| > 1 CL | 51 [50;54] | 66 [65;67] | 79 [78;82] | 93 [92;94] | 157 [155;159] | 226 [224;228] | 275 [269;284] | |
| PV (cm3) | 0 CL | 12.8 ± 8.7 | 43.7 ± 15.1 | 94.4 ± 8.8 | ||||
| 1 CL | 17.8 ± 10.7 | 45.5 ± 16.4 | 98.0 ± 33.8 | |||||
| > 1 CL | 15.2 ± 7.7 | 49.5 ± 21.8 | 102.1 ± 34.7 | |||||
| uPVV (cm3) | 0 CL | 5.1 ± 7.3 | 11.2 ± 4.9 | 19.4 ± 8.6 | ||||
| 1 CL | 3.7 ± 3.3 | 9.9 ± 7.0 | 19.0 ± 10.5 | |||||
| > 1 CL | 2.7 ± 2.7*3 | 10.4 ± 10.1 | 17.4 ± 14.2 | |||||
| UtA RI | 0 CL | 0.82 ± 0.06 | 0.75 ± 0.07 | 0.70 ± 0.15 | 0.59 ± 0.14**1,2 | 0.39 ± 0.05***1,2 | 0.44 ± 0.08 | |
| 1 CL | 0.86 ± 0.08 | 0.81 ± 0.09 | 0.76 ± 0.10 | 0.72 ± 0.10 | 0.54 ± 0.09 | 0.49 ± 0.09 | ||
| > 1 CL | 0.83 ± 0.05*3 | 0.80 ± 0.07 | 0.75 ± 0.08 | 0.71 ± 0.09 | 0.55 ± 0.09 | 0.50 ± 0.07 | ||
| UtA PI | 0 CL | 2.36 ± 0.66 | 1.87 ± 0.53 | 1.92 ± 1.46 | 1.39 ± 0.85*1 | 0.53 ± 0.09***1,2 | 0.62 ± 0.16*2 | |
| 1 CL | 2.75 ± 0.78 | 2.29 ± 0.73 | 1.96 ± 0.69 | 1.68 ± 0.60 | 0.90 ± 0.30 | 0.77 ± 0.27 | ||
| > 1 CL | 2.38 ± 0.50**3 | 2.10 ± 0.46 | 1.81 ± 0.60 | 1.60 ± 0.52 | 0.93 ± 0.29 | 0.78 ± 0.21 | ||
| MAP (mmHg) | 0 CL | 80.8 ± 12.1 | 82.9 ± 9.9 | 84.0 ± 5.1 | 86.2 ± 8.7 | 76.1 ± 8.2 | 75.7 ± 6.7*1 | |
| 1 CL | 80.4 ± 7.0 | 83.0 ± 8.1 | 83.9 ± 8.1 | 82.6 ± 7.5 | 78.5 ± 8.7 | 83.0 ± 9.3 | ||
| > 1 CL | 79.7 ± 7.2 | 81.2 ± 7.1 | 82.7 ± 7.1 | 81.0 ± 6.5 | 78.3 ± 6.7 | 80.5 ± 8.1 | ||
| UmbA RI | 0 CL | 0.68 ± 0.04 | 0.61 ± 0.05 | |||||
| 1 CL | 0.70 ± 0.05 | 0.61 ± 0.07 | ||||||
| > 1 CL | 0.68 ± 0.06 | 0.63 ± 0.07 | ||||||
| UmbA PI | 0 CL | 1.09 ± 0.13 | 0.91 ± 0.11 | |||||
| 1 CL | 1.15 ± 0.16 | 0.94 ± 0.16 | ||||||
| > 1 CL | 1.11 ± 0.17 | 0.98 ± 0.16 | ||||||
| Placental Weight (gram) | 0 CL | 380 [260;426] | ||||||
| 1 CL | 438 [360;514] | |||||||
| > 1 CL | 491 [433;563] | |||||||
Data are presented as (mean ± SD) or median (interquartile range). ***p < 0.001, **p < 0.01, *p < 0.05. 1, statistical difference between 0 CL and 1 CL; 2, statistical difference between 0 CL and > 1 CL; 3, statistical difference between 1 CL and > 1 CL. CL = corpus luteum; GA = gestational age; PV = placental volume; uPVV = utero-placental vascular volume; UtA = uterine artery; RI = resistance index; PI = pulsatility index; MAP = mean arterial pressure; UmbA = umbilical artery