Table 3.
Associations between first-trimester maternal RAAS concentrations and trajectories of utero-placental (vascular) development and placental weight
| Model 1 | Model 2 | ||||
|---|---|---|---|---|---|
| Beta (95% CI) | p-value | Beta (95% CI) | p-value | ||
| First-trimester trajectories (n = 151) | |||||
| PV (∛cm3) | Log [Prorenin (pg/mL)] | -0.04 (-0.19; 0.12) | 0.65 | -0.14 (-0.33; 0.06) | 0.16 |
| Log [Aldosterone/renin ratio] | 0.12 (0.01; 0.22) | 0.04* | 0.12 (0.01; 0.24) | 0.04* | |
| uPVV (∛cm3) | Log [Prorenin (pg/mL)] | -0.08 (-0.27; 0.10) | 0.38 | -0.23 (-0.44; -0.02) | 0.04* |
| Log [Aldosterone/renin ratio] | 0.003 (-0.13; 0.14) | 0.96 | 0.01 (-0.13; 0.14) | 0.91 | |
| Total pregnancy trajectories (n = 201) | |||||
| UtA-RI | Log [Prorenin (pg/mL)] | 0.04 (0.001; 0.07) | 0.04* | 0.10 (0.01, 0.20) | 0.04* |
| Log [Aldosterone/renin ratio] | -0.02 (-0.05; 0.003) | 0.08 | -0.01 (-0.04; 0.01) | 0.27 | |
| UtA- PI | Log [Prorenin (pg/mL)] | 0.05 (-0.03, 0.12) | 0.21 | 0.06 (0.01, 0.12) | 0.04* |
| Log [Aldosterone/renin ratio] | -0.05 (-0.10, 0.01) | 0.08 | -0.03 (-0.09, 0.02) | 0.25 | |
| MAP (mmHg) | Log [Prorenin (pg/mL)] | -0.03 (-0.06, -0.01) | 0.002* | -0.02 (-0.04, 0.01) | 0.14 |
| Log [Aldosterone/renin ratio] | 0.01 (-0.01, 0.02) | 0.34 | 0.01 (-0.01, 0.03) | 0.19 | |
| Second-and third trimester trajectories (n = 201) | |||||
| UmbA-RI | Log [Prorenin (pg/mL)] | 0.01 (-0.004, 0.03) | 0.15 | 0.02 (-0.001, 0.04) | 0.06 |
| Log [Aldosterone/renin ratio] | -0.01 (-0.02, 0.01) | 0.31 | -0.004 (-0.02, 0.01) | 0.55 | |
| UmbA-PI | Log [Prorenin (pg/mL)] | 0.04 (-0.004, 0.08) | 0.08 | 0.05 (0.01, 0.11) | 0.04* |
| Log [Aldosterone/renin ratio] | -0.02 (-0.05, 0.01) | 0.24 | -0.01 (-0.05, 0.02) | 0.43 | |
| At Birth (n = 82) | |||||
| Placental weight (gram) | Log [Prorenin (pg/mL)] | -50.88 (-109.52; 7.76) | 0.09 | -93.82 (-160.30; -27.36) | 0.006* |
| Log [Aldosterone/renin ratio] | 24.72 (-16,77; 66.21) | 0.24 | 36.22 (-7.02; 79.45) | 0.08 | |
Table shows the effect estimates of the repeated measurements model for the associations of logarithmic transformed maternal total prorenin and aldosterone/renin ratio concentrations at 11 weeks gestation with trajectories of PV and uPVV during the first-trimester, UtA RI/PI and MAP throughout pregnancy and UmbA RI/PI during the second-and third trimester in the total study population and the linear model with placental weight at birth. Model 1: adjusted for gestational age, Model 2: adjusted model for gestational age, corpus luteum number, maternal age, maternal smoking, BMI, parity, fetal gender and polycystic ovary syndrome.*p < 0.05. CI = confidence interval; PV, placental volume; uPVV, utero-placental vascular volume; UtA, uterine artery; RI, restistance index; PI, pulsatility index; MAP, mean arterial pressure; UmbA = umbilical artery