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. 2021 Nov 3;22:789. doi: 10.1186/s12864-021-08085-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — A Scatter-plot of measured vs. predicted hypersensitive fraction for 224 ancient TE subfamilies across 125 cell lines (28,000 points), with Pearson correlation. Dashed line: predicted fraction = 0.15. B Heatmap of average H3K27ac enrichment relative to flanking regions in H9 embryonic stem cells at LTR TEs genome-wide, stratified by predicted DNaseI hypersensitivity quartile. C) Scatter-plot of the largest hypersensitive fraction across 125 cell lines for each of the 20 RMSs: measured vs. predicted. Dashed line: predicted fraction = 0.15. D Heatmap of fold enrichment of predicted hypersensitive fraction for 20 RMSs plus LTR7. Only cell lines for which at least one of the 22 TE subfamilies has two-fold enrichment are shown