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. 2021 Oct 20;11:749753. doi: 10.3389/fonc.2021.749753

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Copyright © 2021 Mahmoud, Sanad, Elshimy and Hamdy

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Diagnostic value of LINC00511, miR-185-3p, and miR-301a-3p. (A) Expression levels of targets in BC patients. LINC00511 and miR-301a-3p were significantly overexpressed, and on the contrary, miR-185-3p was reciprocally downregulated in BC patients, (B) receiver operating characteristic (ROC) curves for the investigated biomarkers, (C) Negative Likelihood Ratios (−LR) of the estimated markers; estimated % decrease in probability is large (45%) when −LR = 0.1, moderate (30%) when −LR = 0.1–0.2, and small (15%) when −LR = 0.2–0.5. [All values were obtained using MedCalc software (https://www.medcalc.org/calc). Data were plotted graphically using GraphPad prism software]. ****p < 0.0001. ***p < 0.001. **p < 0.01. *p < 0.05. RQ, relative expression; BC, breast cancer.