Table 2.
Study participants’ clinical and demographic features and targeted ncRNA expression levels.
| Groups (n)/Characteristics (Unit) | Control (25) | BC patients (70) | Statistics |
|---|---|---|---|
| Age (years) | |||
| ≤50 (n, %) | (10, 40%) | (39, 55.7%) | χ 2 = 1.821, p1 = 0.244 |
| >50 (n, %) | (15, 60%) | (31, 44.3%) | |
| BMI (kg/m2) | |||
| <25 (n, %) | (20, 80%) | (3, 4.3%) | N.A |
| ≥25 (n, %) | (5, 20%) | (32, 45.7%) | |
| N.A (n, %) | (0, 0%) | (35, 50%) | |
| No. of offspring | |||
| ≤2 (n, %) | (17, 68%) | (38, 54.3%) | χ 2 = 1.42, p1 = 0.233 |
| >2 (n, %) | (8, 32%) | (32, 45.7%) | |
| TLC (×103 cell/µl) | |||
| ≤5 (n, %) | (20, 80%) | (25, 35.7%) | |
| >5 (n, %) | (5, 20%) | (45, 64.3%) | |
| Hemoglobin (gm/dl) | |||
| ≤10 (n, %) | (1, 4%) | (54, 77.1%) | |
| >10 (n, %) | (24, 96%) | (16, 22.9%) | |
| Platelet count (×103cell/µl) | |||
| ≤150 (n, %) | (2, 8%) | (12, 17.2%) | |
| >150 (n, %) | (23, 92%) | (58, 82.8%) | |
| Menopause | |||
| Pre (n, %) | (17, 68%) | (40, 57.1%) | χ 2 = 0.904, p1 = 0.341 |
| Post (n, %) | (8, 32%) | (30, 42.9%) | |
| Non-Communicable Diseases | |||
| C.V.D. (n, %) | (0, 0%) | (32, 45.7%) | N.A |
| D.M. (n, %) | (0, 0%) | (9, 12.9%) | |
| None (n, %) | (25, 100%) | (29, 41.4%) | |
| BC Family History | |||
| No (n, %) | (25, 100%) | (54, 77.1%) | |
| Yes (n, %) | (0, 0%) | (16, 22.9%) | |
| Pt. Surgical History | |||
| No (n, %) | (25, 100%) | (40, 57.1%) | N.A |
| Yes (n, %) | (0, 0%) | (30, 42.9%) | |
| Hormonal Contraceptive Intake | |||
| No (n, %) | (25, 100%) | (53, 75.7%) | N.A |
| Yes (n, %) | (0, 0%) | (17, 24.3%) | |
| CEA (ng/ml) | 1.4 (0.99–1.87) | 2.39 (0.3–6.6) | NS |
| CA15-3 (U/ml) | 6.8 (4.3–17.2) | 23.8 (6.3–90.6) | p2 < 0.0001* |
| LINC00511 (Fold change) | 0.008 (0.0002–0.97) | 2.5 (0.018–21.77) | p2 = 0.006* |
| miR-185-3p (Fold change) | 2.14 (0.53–3.04) | 0.55 (0.01–2.76) | p2 = 0.0001* |
| miR-301a-3p (Fold change) | 0.24 (0.01–1.66) | 3.4 (0.14–20.6) | p2 = 0.0004* |
Data shown as mean ± S.E.M. or median (range) or (n, %), Statistics were computed using GraphPad prism software using Chi square test χ2 (dichotomous parameters), Student’s t-test (parametric data), or Mann–Whitney test (non-parametric data), p1 indicates comparison between number of populations in control and BC groups using Chi-square test, while p2 indicates comparison between mean or median of population in control and BC groups, *Statistical significance p-value < 0.05. [BMI, body mass index; C.V.D., cardiovascular diseases; D.M., diabetes mellitus; TLC, total leucocyte count; N.A., not applicable/not available; NS, non-significant].