Table 1.
Properties of different PMX forms.
| Test material | Particle size (nm) | Polydispersity index (PDI) | Zeta potential (mV) | Apparent permeability (Papp, ×10−6 cm/s) | Effective permeability (Peff, ×10−4 cm/s) |
|---|---|---|---|---|---|
| PMX | 1.20 ± 0.349 | 0.830 ± 0.044 | |||
| PMX/DL(1:1) | 1116 ± 394 | 0.878 ± 0.109 | 16.0 ± 0.954 | 3.24 ± 0.314*** | 2.71 ± 0.908 |
| PMX/DL(1:2) | 176 ± 4.95 | 0.397 ± 0.014 | 0.340 ± 0.290 | 4.76 ± 0.595***,### | 3.27 ± 0.964 |
| PMX/DL(1:1)-CD | 175 ± 2.01 | 0.157 ± 0.019 | 12.5 ± 0.850 | 5.59 ± 0.409***,###,$ | 5.97 ± 1.26** |
| PMX/DL(1:2)-CD | 193 ± 2.72 | 0.187 ± 0.005 | 19.3 ± 0.557 | 6.09 ± 0.724***,###,$$$ | 6.92 ± 3.36**,# |
Apparent permeability (Papp) and effective permeability (Peff) values of PMX with or without DL, Kolliphor P188, and Labrasol alone or in combination through a Caco-2 cell monolayer (n = 7) and the rat intestine (n = 4). Values represent means ± SDs.
**p < .01, ***p < .001 compared to PMX.
#p < .001, ###p < .001 compared to PMX/DL(1:1).
$p < .05; $$$p < .001 compared to PMX/DL(1:2).