Table 2.

Antitumour effects of SSD in vivo.

Cancer type	Animal models	Concn.	Administration	Duration	Suggested mechanism	Ref.
Hepatoma	HSVtk/Hep3B cells xenograft tumour in nude mice	10 mg/kg	Intraperitoneal injection	Every other day for 33 days	Inhibition of growth. Promotion of apoptosis. Chemosensitization (HSVtk/GCV)	(Zhang et al. 2019)
Lung cancer	HCC827/GR cells xenograft tumour in nude mice	5, 10 mg/kg	Not mentioned	Every day for 14 days	Inhibition of growth. Promotion of apoptosis. Chemosensitization (gefitinib)	(Tang et al. 2019)
Breast cancer	MCF-7/ADR cells xenograft tumour in nude mice	5 mg/kg	Intraperitoneal injection	Every other day for 20 days	Inhibition of growth. Inhibition of P-gp expression. Reversal of MDR without toxic effect.	(Li, Xue et al. 2017)
Thyroid carcinoma	ARO cells xenograft tumour in nude mice	5–20 mg/kg	Oral gavage	Every day for 4 weeks	Inhibition of growth.	(Liu and Li 2014)