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Flowchart of the process of CT image segmentation and VOI construction. An example of primary tumor segmentation and VOI construction for patients with central lymph node metastasis. VOI segmentation is performed on unenhanced and contrast-enhanced computed tomography images (A). Features are extracted from the VOI of primary tumor (B), including tumor shape, intensity, and texture. The VOI of primary tumor can be shown in a 3D status (C). VOI, volume of interest.
